This study was carried out in Fetal Medicine Unit CAIFM in Obstetrics and Gynecology Department at Cairo University, from January 2012 till November 2013. Three hundred pregnant women at 11-13+6 weeks were included in this study. All included cases were subject to the following: explanation of the study and oral informed consent, full history taking, full first trimesteric anomaly scan with detailed heart examination and ductus venosus waveform assessment, then reassessment at 18-20 weeks followed by postnatal cardiac exam of the neonates with a neonatal 2D Echocardiography done if an anomaly is suspected sonographically or clinically.