In pregnant women, antiphospholipid syndrome (APS) is associated with an increased risk of preeclampsia, fetal intrauterine growth restriction, and other complications related to uteroplacental insufficiency. In the last two decades, several studies were performed to identify the predictive role of some parameters in relation to obstetric outcome in APS patients. Doppler ultrasound has been used to measure the blood flow velocity in vessels during the cardiac cycle.DV flow plays a fundamental role in fetal hemodynamics. The aim of this study is to determine the role of Doppler velocimetry of the umbilical arteries, and amniotic fluid index in the prediction of fetal distress during the third trimester in patients with antiphospholipid syndrome.