Bladder cancer accounts for about 30% of all cancers in Egypt. Urothelial carcinoma represents approximately 90% of all primary tumors of urinary bladder. Aim of the work: Is to evaluate the expression of cyclooxygenase-2 (COX-2) in the urothelial carcinoma of the bladder and its correlation with prognostic indices of the tumor. Material and methods: This study included 40 urothelial bladder carcinoma specimens obtained by radical cystectomy and pelvic lymphadenectomy. Results: There was no statistically significant relationship between COX-2 expression and most of the different clinico-pathological factors while there was statistically significant relationship between COX-2 expression and the grade of the tumors. Conclusion: There was statistically significant relationship between COX-2 expression and the grade of the tumors. Further studies were needed to determine the possibility of considering COX-2 expression in the urothlial carcinoma a prognostic factor.