A retrospective study conducted in Pediatric Hematology Clinic, New Children Hospital, Cairo University, from January to April 2013, to assess beta-2- microglobulin (B2M) levels in in 68 Egyptian children, aged 1 to 18 years. Patients were presented in Hematology Clinic with a steady state of SCD. Their mean serum B2M was normal (1.92±0.757 ug/ml). Although, serum B2M was within the reference range, cases had significantly lower serum B2M to the control group. Serum level of B2M was not affected by gender and our data clearly demonstrate age independency for serum concentrations of B2M. We concluded that serum B2M is not a good marker in the detection of early stages of SCD nephropathy in children. The study recommends further investigation on a larger scale to determine the magnitude of the problem in Egypt.