Liver steatosis is a characteristic common feature of important liver diseases such as chronic hepatitis C. Fatty acid synthase (CD95/FAS) the member of the tumor necrosis factor family (TNF) is the protein most strongly associated with the production of fatty acids and steatosis. The present study was done on 100 archival blocks of patients infected with chronic hepatitis C virus, Each paraffin block was re-cut by rotatory microtome at 5 microns thickness then mounted on glass slides to be stained by hematoxlyin and eosin (H&E) for routine histopathological examination and on charged slides for immunostaining, steatosis also examined according to scoring system of Kleiner et al. The age incidence ranged from 21 up to 59 years. In the studied cases the male gender constituted 67%, while female gender constituted 33% of cases. The highest FAS expression was found in grade 0 steatosis while the lowest expression was in grade 3, this result was significant and suggesting an inverse relationship between steatosis grades and FAS expression. FAS expression was higher in males than in females, while there was no significant association between FAS expression and patient's age. There was also no association between steatosis and necroinflammation grade or fibrosis stage.