Chronic liver diseases and cirrhosis are now being recognized as an important cause of morbidity and mortality worldwide. Established cirrhosis has a 10-year mortality of 34-66%. Hepatorenal syndrome and spontaneous bacterial peritonitis are important cause of mortality in cirrhosis. Cirrhotic patients frequently evaluated for the presence of such complications by using old methods namely Child-Pough and MELD scores, and due to some shortages in MELD score with short survival rate within 3 months making a medical burden due to finding a new class of biomarkers. The aim of the present study was to evaluate miR-122 as a prognostic marker in patients with liver cirrhosis.