Background: VEGF has a role in various diseases involving endothelialcells including lupus glomerulonephritis caused by immune complexdeposition.Objectives: to study the association between VEGFpolymorphism with susceptibility to SLE as well as lupus nephritis and itsrelation to VEGF protein level.subjects and methods:Acase control studyinvolving 40 SLE patients without nephritis and 40 SLE patients withnephritis and 20 healthy controls. Polymerase chain reaction andrestriction fragment lenght polymorphism(PCR- RFLP)methods wereapplied to detect polymorphism in VEGF promoter +405 and -460 andVEGF protein level was measured by ELISA.Results:. There was asignificant difference in the VEGF 405 GG (52.5%) and VEGF TT 460(57.5%) genotypes in lupus nephritis patients compared to the controlsubjects (35%) ,(45%) respectively. The frequency of the G allele of theVEGF promoter 405was higher in the lupus nephritis patients (73.7%)than in the control subjects (62.5%) and SLE (65%) The frequency ofthe T allele of the VEGF promoter 460 was higher in the lupus nephritispatients (73.7%) than in the control subjects (65%) and SLE (72.5%).VEGF protein level was higher in lupus nephritis compared to SLEwithout nephritis and control groupsConclusion: There was no association between VEGF+ 405 and -460polymorphism and SLE susceptibility. However, it was associated withlupus nephritis and increased VEGF protein level.