The percentage of type II diabetes mellitus continues to increase where as the proportion of type I diabetes mellitus remain stable.Renal disease is widely recognized complication of non insulin dependent diabetes mellitus(NIDDM),but it’s development and course are difficult to characterize because of uncertainties in dating the onset of diabetes.It’s protracted cause and because of high prevalence of non diabetic renal disease in some population.Diabetic nephropathy is the leading cause of end-stage renal disease worldwide and is associated with increased cardiovascular risk.The earliest clinical manifestation is microalbuminuria .Once microalbuminuria is present, the rate of progression to end-tage renal diease.The presence of significant level of non-heme iron in the erythrocytic ghost membrane of (NIDDM),subjects is an indication of the potential for iron catalysed production of hydroxyl and other toxic radical which could cause continous oxidative stress and tissue damage.Oxygen derived free radical could therefore be responsible for most of tissue damage in diabetic complication.