In our study, we found a significant positive correlation between the expression of CD36 and the expression of both CD71 and CD49d. While a significant negative correlation was found between CD36 expression and percent of HBF. A significant positive correlation was found between the expression of CD71 and the expression of CD49d. While a significant negative correlation was found between CD71 expression and percent of HBF. Results of a correlation study between level of CD49d expression and percent of HBF in our research pointed to a significant positive correlation between the expression of CD49d and percent of HBF. Thus from the present study as well as other previous studies it can be stated that treatment of sickle cell anemia with hydroxyurea causes a significant increase in HBF together with a significant reduction of CD36, CD71 and CD49d adhesion molecules and AnnexinV expressions on the surface of erythrocytes, a fact that may explain part of the beneficial effects of this type of treatment. Lastly, these findings could have clinical relevance, as inhibition of adhesion receptor expression or activity could be a novel new therapeutic approach for the patient with SCD.