This is a retrospective study of the record of 86 patients with pathologically proven bone tumors and they were treated with chemotherapy. They were all treated in National Cancer Institute (NCI) and Cairo University Hospital over the period of 13 years from January 1993 to January 2006. The overall survival of all studied cases was 71.4%. Functional outcome was calculated according to MSTS scoring system and 70% of our patients had functional outcome of more than 70%. Various prognostic factors and chemotherapy toxicities were analyzed.