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38010

Psoriasis and insulin resistance

Thesis

Last updated: 06 Feb 2023

Subjects

-

Tags

Dermatology, Andrology and STDs

Advisors

El-Ramli, Amani Z., El-Tawdi, Amira M., Shaker, Ulfat G.

Authors

Muhammad, Nuha El-Shahhat

Accessioned

2017-04-26 12:03:55

Available

2017-04-26 12:03:55

type

M.Sc. Thesis

Abstract

Background: Psoriasis as a chronic inflammatory skindisorder is characterized by a variety of immunologic andinflammatory changes that may predispose to peripheral insulinresistance and the development of type II diabetes mellitus (DM).In our study, we tried to detect the relation between impairedglucose tolerance (IGT), insulin resistance (IR) and psoriasis andtheir possible correlations to severity of psoriasis.Materials and Methods: This study comprised 30psoriatic patients and 30 controls. All cases were subjected tocomplete history taking, clinical examination including psoriasisarea and severity index (PASI) score. Serum blood glucose levels(fasting and 2-h postprandial) were estimated and ELISAtechnique was applied in order to measure the fasting seruminsulin levels. Impaired glucose tolerance (IGT) was estimatedbased on fasting and 2-h postprandial blood glucose levels.Detection of insulin resistance was achieved by evaluation ofinsulin sensitivity and beta cell function indices, which wereapplied on all patients and controlsResults: Results showed that 16.7% of patients had insulinresistance (IR) with compensatory hyperinsulinaemia, where as,33.3% had impaired glucose tolerance (IGT) with decline in betacell function in comparison to normal controls with no significantcorrelation to severity of the disease (measured by PASI score).Conclusions: Our study demonstrated significant increaserates of both impaired glucose tolerance and insulin resistance inpsoriasis. The detection of IR has an important value in reducingthe risk DM and prevents its complications and other componentsof insulin resistant syndrome (IRS) in psoriatic patients.

Issued

1 Jan 2008

DOI

http://dx.doi.org/10.21473/iknito-space/31954

Details

Type

Thesis

Created At

05 Feb 2023