Atherosclerosis is considered one of the most common chronic diseases widely spread in the world nowadays. There are many factors that contribute to the occurrence and the development of this disease. The most common factors that predispose to this disease are excess eating high-fat content diet, decreased physical activity and exposure to social stress in our daily life. In this study, we aimed to study the effect of high fat diet, psychological stress and androgen deprivation in the progression of atherosclerosis. Moreover, we tried to find the impact of testosterone replacement therapy and oxytocin and their combined effects in attenuating the events of this disease. Thus the present study aimed to investigate the role of these hormones as athero-protective agents through estimation of the serum lipid profile, inflammatory markers (hs-CRP and IL-6) and serum adiponectin. The gene expression levels of interleukin-6, estrogen receptor alpha and adiponectin receptors 1 and 2 were also evaluated.