An essential perquisite for clear good vision is to have a smooth corneal surface epithelium supporting an intact tear film. Physiologically, a natural turnover of corneal epithelial cells occurs in which superficial cells shed from the epithelial surface and replaced by those from underneath. In turn, basal epithelial cells migrate inward from the periphery, replenishing the population of the deeper corneal epithelial cells. The source for new cells to keep the integrity of this system is believed to be the corneal epithelial stem cells, which are strongly thought to reside mostly in the palisades of Vogt in the limbal region. The SC niche hypothesis model proposed by Schofield in 1983, suggests the importance of intrinsic properties (characteristics inherent to the cell) and extrinsic properties (characteristics of the SC environment) in maintaining “stemness.” The limbus and particularly the palisades of Vogt are thought to contain the CESC niche. If the palisades of Vogt at the limbus represent the LSC niche, then the basement membrane and stromal matrix in this zone must be different from that seen in the central cornea to allow the “stemness” of these cells to be maintained. Indeed, the limbal epithelium of the palisades of Vogt has many differences (characteristics) from the central corneal epithelium.