Hyperpigmentation is skin darkening which may be the result of several different pathophysiologic processes. The treatment of hyperpigmented disorders is a difficult task. Depigmenting agents are classified into : Chemical agents, physical agents, novel methods and adjuvant lines of therapy. Each method has its indications, contraindications and side effects which should be fully understood. This is very important for the proper choice of treatment aiming to reach the best results, with the least possible complications.