Background: Smoking is one of the most serious problems threatening general health. Smoking greatly affects the microcirculatory vasculature, from cutaneous microcirculation to cerebral, cardiovascular…etc.Objectives: The goal of this work is to study the effect of cigarette smoking on cutaneous microcirculation in habitual smokers in comparison to that of non-smokers.Methods: Thirty normal, healthy, adult, Egyptian males were included in the study. Fifteen were known habitual smokers, and the rest were control. Assessment of cutaneous perfusion and skin blood flow in the fingers was done using Laser Doppler Flowmetry Periflux 5000 (Satellite Perimed Sweden) by thermal stimulation.Results: The Comparative study between control and smoker subjects concerning LDF recorded data; showed that there was a significant higher minimum flux in smokers compared to control group (P = 0.019), also a significant lower maximum, mean and percent change flux in smokers compared to control group (P = 0.001, 0.001, 0.01) respectively. Which denotes the altered microcirculatory-vasomotion in smokers exerted by chronic tobacco toxicity.Conclusion: Habitual smokers exhibit altered microcirculatory vasomotor reflexes expressed in chronic vasoconstriction and reduced peripheral blood flow compared to normal nonsmokers that was shown in this study using the recent sensitive LDF with the aid of thermal stimulation technique.