Endocrine disorders such as obesity, acromegaly, diabetes mellitus and thyroid diseases including goitre and malignancies may adversely affect the airway and increase the risk of difficult intubation with increased morbidity and mortality in the perioperative period. The aim of this review is to focus on how these disorders may affect the airway and how they can be managed whether regarding predicting or overcoming any difficulty with airway management. A thorough history and careful examination will provide warning against many pitfalls in airway management. Proper preparation should allow the anaesthesiologist to develop and execute an anaesthetic plan that is safe and comfortable for the patient.