The aim of this study was to detect the presence of KAL 1 gene deletions in Egyptian male patients complaining of hypogonadotropic hypogonadism associated with anosmia (Kallmann’s syndrome).Fourteen patients were included in this study, suffering from hypogonadotropic hypogonadism associated with anosmia, evidenced by their low FSH, LH and Testosterone plasma levels(group I). They were recruited from Andrology and STD's out patient clinic, Kasr EL Eini Hospitals, Cairo University and Dermatology and Andrology out patient clinic, National Research Centre. Another six males complaining of hypogonadotropic hypogonadism were recruited as a control group (group II). They were recruited from Andrology and STD's out patient clinic, Kasr EL Eini Hospitals, Cairo University and Dermatology and Andrology out patient clinic, National Research Centre.