Inflammation of the kidney vasculature may give rise to a proven protean range of clinico-pathological outcome. Ceruloplasmin is an acute phase protein that has antiproteinase and antioxidant properties and inhibits myeloperoxidase (MPO) activity. Ceruloplasmin takes part in the clearance and inactivation of myeloperoxidase. The impaired inactivation of MPO may have a pathological role in inflammatory diseases characterized by autoantibodies to MPO, such as rapidly progressive glomerulonephritis with P-ANCA. Diagnosis of vasculitides remains of paramount importance to ensure early approach to the patients and henceforth good prognosis. This study which encompassing eighty cases and twenty controls is temptingly supporting Ceruloplasmin as a would-be reliable predictor of vasculitis; a very useful early diagnostic test of vasculitis, since within a substantial number of variable vasculitidies, the Ceruloplasmin has been shown to be significantly elevated. Early on in the pathologic process, and remaining so for a perceptible time after other acute phase proteins would have been decaying.