Liver cirrhosis is a pathological condition associated with hyperdynamic circulation characterized by increased regional blood flow and generalized vasodilatation which causes eventually arterial hypotension.The aim of this study was to investigate the factors involved in the pathogenesis of some of the cardiovascular abnormalities associated with liver cirrhosis.In this work, 40 rabbits were chosen for the experiments. The rabbits were randomly divided into two groups in which group 1 represented the control group and group 2 was the cirrhotic group. Induction of cirrhosis was done by administration of 70% ethanol alcohol intraperitoneally by dose 10 ml/Kg body weight.Arterial hypotension which has been observed in liver cirrhosis was associated with: elevated plasma noradrenaline, increased secretion of vasodilators such as nitric oxide and prostacyclin, but nitric oxide plays the main role in the pathogenesis of this abnormality.Further studies are needed to focus the light on the other factors responsible for the different haemodynamic abnormalities in liver cirrhosis.