The study include 100 cases of breast cancer collected from Pathology Department, Faculty of Medicine Cairo University were a assessed histopathologically for tumour site, size, grade, microscopical type, vascular emboli, necrosis mitotic count and axillary lymph node metastasis. Immunohistopthalogical study of neovascularization in breast carcinoma highlighting microvessel formation were detected by monoclonal antibody CD31, expression of bcl-2 cytoplamsic immunoreactivity and. Correlation between them and tumor site, size, grade microscopical type, vascular emboli, necrosis, mitotic count and axillary lymph node metastasis. The female to male ratio was 49:1. There was a statistical correlation between bcl-2 immunoreactivity and tumour grade, necrosis and mitotic count. There was a highly inverse relation of bc1-2 immunoreactivity with apoptotic percentage. We concluded that neovascularization is an early phenomenon in breast neoplasia and is apparent as early as the in situt stage. The role of bcl-2 oncogen is very interesting because of its role in the early stages of breast carcinoma progression as well as its associated functions in triggering the inhibition of apoptosis.