Studies were performed in the gastrointestinal tract revealed the presence of endocrine cells interspersed among nonendocrine. Many, of these cells are able to take up amine orecursors and to exhibit amino acid decarboxylase activity. This explains the acronym APUD by which they are known. Recently this name has been replaced by DNES. The DNES cells were identified in this study by silver staining and localized by immunocytochemical methods using chromogranin A, gastrin, and somatostatin. GA-IR cells were demonstrated in all segments of the GIT. Gastrin –IR cells were located at the pylorus and duodenum, while Somatostatin –IR cells were detected through the GIT wxcept in the fundus and rectum. Both the open and closed types of cells were seen. Inspite of the large studies concerning the neuroendocrine cells there is many points of controversy about their origin, morohology, the hormone produced by each cells and even their names. Accordingly this subject required more research.