The formation of this sugammadex/NMBA complex results in a reduction in the amount of free circulating NMBA, leaving the receptor available for binding to Ach .Any degree of neuromuscular block produced by rocuronium or vecuronium can be rapidly and completely reversed without autonomic effects. Because sugammadex is optimized for reversing rocuronium it is most likely to be used in conjunction with this drug.Sugammadex was three times more rapid than edrophonium and its onset time is about 10 times more rapid than neostigmine. Neither atropine nor glycopyrrolate was needed with sugammadex, these patients’ ouths were not as dry as with neostigmine or edrophonium.