Over the past 30 years, the methods available for lip rejuvenation and for correction of wrinkle lines increased exponentially with the advent of new skin filler substances, improved techniques for elevating existing scars, and technology for abrading and resurfacing facial contours. Seemingly every month, a new and improved filling agent or laser, which will be the best of all available methods, becomes available. In the c of these technological breakthroughs, the basic mechanisms remain the same. The goal for research and development in this field over the past 50 years has been the synthesis of the ideal filler substance for skin and soft-tissue augmentation. This filler substance may be a physiologic (biologic) substance or a synthetic one. Physiologic filling materials such as dermis, fascia, and fat have been used as autologous implants for many years, with specific surgical techniques used for each. These remain in use today but on the whole are cumbersome and complicated surgical operations with associated adverse effects and complications. Injectable synthetic filling materials included cutting oils, paraffin, and silicone, each with its own adverse effects and complications. Other techniques available for lip rejuvenation include: laser resurfacing, chemical peeling and lip tattooing.