Osteoarthritis (OA) is the most common joint disorder worldwide It is a chronic degenerative disorder characterized by cartilage loss. OA prevalence is high, and it is a major cause of disability. Numerous factors have been associated with an increased risk for the development of OA; these include systemic factors such as genetics, age and gender as well as local mechanical factors such as joint injury , joint deformity and muscle weakness .Therapies for OA have been directed mostly toward the alleviation of signs and symptoms of the disease, predominantly manifested by pain. Evaluating therapeutic efficacy has largely focused on improvement in pain and joint function.Management of OA, the most common form of arthritis, involves a combination of nonpharmacological, pharmacological, and surgical options in advanced cases. As the populations of developed nations age over the next few decades, the need for better understanding of osteoarthritis and for improved therapeutic alternatives will continue to grow.