Background: Obesity being a common medical problem due to its complications such as atherosclerosis, diabetes mellitus etc., a number of studies were directed towards its causes. Among these causes is drug intake e.g. some antiepileptic drugs, oral contraceptive pills and others. Accordingly the present study is focused on weight gain observed with antiepileptic drugs and its relation to leptin and insulin hormones. Objective: The aim of this work is to study the role played by leptin and insulin hormones in weight gain induced by antiepileptic drugs. Subjects and Methods: This study was carried out on 40 epileptic patients, and 19 healthy subjects, where leptin, insulin levels and BMI were measured in both groups. Results: There was high statistically significant difference in insulin and leptin hormones between cases and controls as well as a statistically significant difference in leptin levels between valproate and carbamazepine subgroups being higher in valproate treated patients. Conclusion: The increased serum leptin levels was not associated with increased body weight in epileptic patients as assessed by BMI but was more influenced by anti-epileptic drug intake, especially valproate.