Systemic lupus erythematosus (SLE) patients have a significantly increased riskof coronary heart disease (CHD) that is not fully explained by classic risk factors. Endothelialdysfunction is an early stage in the process of atherogenesis. is to assess whether endothelialdysfunction in SLE.Objective: is to assess whether endothelial dysfunction in SLE.Methods: We studied 37 women with SLE and 10 healthy women. Demographic and risk factor data will be collected. In patients, disease activity and treatment-related parameters arealso assessed. Endothelial function is assessed by flow-mediated dilation (FMD) in the brachial artery in response to reactive hyperemia as well as carotid intima-media thicknessand the presence of carotid plaques is also assessed in the study population.Conclusion: there was no statistically significant correlation between FMD and SLE or itsactivity or any of the clinical or laboratory findings except with cholesterol and hemoglobinlevel.