In this study, we were aiming to find a relation between H. pylori and progression of HCV related liver disease by comparing the sero-prevalence of H. pylori in HCV sero-negative and sero-positive (cirrhotic & non-cirrhotic) patients. H. pylori status was investigated using ELIZA technique in 30HCV positive cirrhotic patients, 30HCV positive non-cirrhotic patients and 20healthy controls. The study showed higher prevalence of both H. pylori IgG and IgA in cirrhotics (100%,80%) respectively, than non-cirrhotics (90%,46.7%) and controls (65%, 20%). No relation was found between H. pylori infection and sex or age.