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Effect of metformin onclomiphene induced ovulationin the polycystic ovary disease

Thesis

Last updated: 06 Feb 2023

Subjects

-

Tags

Obstetrics and Gynecology

Advisors

El-Ahwani, Tharwat M., Ebrahim, Gamal A., El-Halwagi, Ahmad M.

Authors

Ahmad, Shaker Muhammad

Accessioned

2017-03-30 06:22:42

Available

2017-03-30 06:22:42

type

M.Sc. Thesis

Abstract

Polycystic ovary syndrome (PCOS) is classically defined as chronic anovulation in the presence of hyperandrogenism of ovarian origin . The proximate cause of anovulation in PCOS is inappropriate gonadotrophin production with relative excess in secretion of luteinizing hormone (LH) to follicle stimulating hormone (FSH) which result in an increase in ovarian androgen production. The end result of this state of hormonal imbalance is hirsutism , bilateral polycystic ovaries and anovulation . Insulin resistance is observed frequently in both obese and normal weight women with polycystic ovary syndrome and independent of obesity . Currently treatment consists of weight reduction for women who are obese for those who wish to conceive clomiphene citrate may be given if that is unsuccessful assisted- reproduction procedures be tried for the remaining women . Drugs like metformin that increase insulin sensitivity and decrease hyperinsulinemia can reduce androgen secretion and by raising serum sex hormone binding globulin concentration, also limit the action of androgens.

Issued

1 Jan 2003

Details

Type

Thesis

Created At

05 Feb 2023