Aim: This study aimed to compare the push-out bond strength of MTA FILLAPEX and AH Plus sealers after final rinse with different irrigation protocols.Methodology: Sixty extracted human single rooted teeth were used in this study. All canals were prepared with Revo-S rotary nickel titanium files for standardization. The selected specimens were randomly divided into two main equal groups (n=30), according to the obturation material that was used; Group I: canals were obturated with Gutta-percha + MTA FILLAPEX sealer, And group II : canals were obturated with Gutta-percha + AH Plus sealer. Furthermore each main group will be subdivided into 3 subgroups (n=10), according to the final irrigant type; Subgroup A: Final irrigation with 5.25% NaOCl. Subgroup B: Final irrigation with 17% EDTA. And subgroup C: Final irrigation with 25 % Citric acid. . Three horizontal sections of 2-mm thickness were cut from coronal, middle and apical thirds of each root.The test specimens were subjected to the push-out test using a Universal Testing Machine software and loaded at a crosshead speed of 0.5 mm\min. Load applied by 3 plungers of different sizes (1 mm, 0.75 mm & 0.5 mm) corresponding to Cervical, middle and apical specimens, respectively. The data were analyzed by using ANOVA and Duncn post-hoc tests, with significance set at P≤ 0.05.Results and Conclusion: it was found that AH-Plus recorded higher bond strength mean value (3.62 ± 0.3 MPa) than MTA Fillapex (0.905 ± 0.21 MPa) (P<0.05).In terms of irrigant used; it was found that NaOCl group recorded highest push out bond strength mean value (2.541± 0.1314) followed by EDTA group (2.362 ± 0.1278) while Citric acid group recorded lowest mean value (2.011 ± 0.1920) (P<0.05) .In terms of root segments; it was found that cervical region recorded highest push out bond strength mean value (2.538 ± 0.2222 Mpa) followed by middle region (2.283 ± 0.1121 Mpa) while apical region recorded lowest mean value (2.145 ± 0.1509 Mpa) (P>0.05) .