Background: Fetal kidney weight cannot be measured in utero, renal volume measured by U/S is a valid substitute. With the latest developments in the field of three dimensional U/S, accurate assessment of the fetal organ volume has become feasible and this technique has gained widespread application in different medical fields. We also aimed to examine the association of renal artery, umbilical artery and middle cerebral artery resistance index with fetal kidney volume. Objective: Intrauterine growth restriction may lead to renal disease and hypertension in adult life. This study was performed to determine whether renal volume differs between fetuses that are intrauterine growth restricted and fetuses that are not. We also aimed to examine the association of fetal blood flow parameters with the fetal renal volume. Design: Prospective descriptive study.Setting: Fetal Medicine Unit, Department of Obstetrics and Gynecology-Cairo University Hospitals-Kasr El Aini. Patients and Methods:Fetal biometry was examined in 64 pregnant women between 27-36weeks of gestation. Women was divided into 2 groups; mothers with IUGR (group A, n=32) and mothers within normal range fetal biometry i.e. control group ( group B, n=32). In all participants, total renal volume was measured using 3D U/S and umbilical, middle cerebral as well as fetal renal artery resistance index which was calculated using color Doppler technique. All measured parameters were compared to fetal growth stage and correlated to the total renal volume.Results: The mean total fetal renal volume was 10.26 2.62 in group Aand 16.85 5.35 in group B. (p value < 0.05). Head circumference,abdominal circumference and estimated fetal weight were positivelycorrelated with the total renal volume "TRV" in both groups "r=0.7, 0.72,0.8 respectively in Gp B, and 0.7, 0.6, 0.7 respectively for Gp A, with astatistically significant p value for both groups". Umbilical artery resistance index was inversely correlated with the total renal volume in group B (r = -0.70, p 0.002). The middle cerebral artery resistance index did not show a significant correlation with the TRV in group B "r = 0.37, p=0.13" in contrast to the control group where a significant negative correlation existed between the 2 parameters "r = - 0.4, p = 0.0001". Renal artery resistance index there is no significant correlation with the TRV in both groups " r = 0.4, p= - 0.7 in Gp B, and r = 0.17, p = 0.02 for Gp A". Conclusion: The conclusion of our study is that intrauterine growth restriction appears to be associated with a decrease in the fetal renal volume. This study supports the hypothesis that intrauterine growth restriction may be linked to renal disease and hypertension in late life.