Objective : This work was designed to explore a recent insight on prevalence of HCV infection among Egyptian thalassemic children.Methodology : The study was conducted on 168 thalassemics, 50 sickle cell anemia patients and 20 healthy control subjects. Full history, clinical and laboratory evaluation was done. Results : Prevalence rate of HCV infection was 40.5 % among thalassemics, 50 % among sickle cell anemia patients and 5 % in control subjects.Anti-HCV seropositivity increased with increased duration of transfusion, increased age and high levels of serum ferritin.Anti-HCV seropositive thalassemics showed worsening of their condition including more hepatosplenomegaly, bleeding tendency, growth retardation and more elevated liver transaminases indicating progressive liver damage.Conclusion : Inspite of introduction of blood screening and donor selection and decline in prevalence, HCV infection is still a major risk among thalassemics and more concern needs to be directed towards this issue.