Background: Endothelial dysfunction has been regarded to as an early stage in the atherosclerotic process and could be evaluated by invasive methods (as catheterization ) and non invasive methods (as endothelial microparticles as Cadherin 5 and Annexin V). Aim of the work: This study tries to identify circulating endothelial MPs (such as Cadherin 5 and Annexin V) as potential new risk factors in the occurrence of cardiovascular events in patients with chronic renal diseases. Subjects and Methods: Cadherin 5 and Annexin V were measured in 20 healthy control, 25 patients of chronic renal disease without ischemic cardiovascular complications (Group I) and 35 patients of renal kidney disease with ischemic cardiovascular complications (Group II) by the quantitative sandwich ELISA technique.Results: Serum Cadherin 5 was 31.69 ± 11.23 ng/ml in group I and 86.99 ± 21.51 in group II with highly statistical significant difference to control group (2.63 ± 1.47) {p < 0.01}. Also, group II showed highly statistical significant difference when compared to group I { p < 0.01 }. Cadherin 5 recorded a high specificity (99.96%) and sensitivity (97%) at cut off 46.8 and area under the curve was 0.998. Serum Annexin V was 27.26 ± 11.87 ng/ml in group I and 83.73 ± 22.64 in group II with highly statistical significant difference to control group (0.47 ± 0.36) {p < 0.01}. Also group II showed highly statistical significant difference when compared to group I { p < 0.01 }. Annexin V recorded a high specificity (99.88%) and sensitivity (94.3 %) at cut off 39.15 and area under the curve was 0.993. Cadherin 5 and Annexin V are more sensitive than C-reactive protein ( at cut off 36.0 sensetivity was 71.4 and specificity was 99.6 ). A significant direct correlation was found between levels of Cadherin 5 and Annexin V .An inverse correlation was found between Cadherin 5 and Annexin V in one hand and ejection fraction in the other hand in patient group. A significant direct correlation was found between levels of Cadherin 5 and Annexin V in one hand and CRP and ESR in the other hand.Conclusion: Serum Cadherin 5 and Annexin V is elevated in patients with chronic kidney disease and is considered non-traditional risk factors for prediction of cardiovascular complications especially atherosclerotic ischemic heart disease, thus permitting a new therapeutic strategies of cardiovascular complications in patients with chronic kidney disease.