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Hepatitis C virus recurrence in deceased and living donor liver transplantation : A comparative study

Thesis

Last updated: 06 Feb 2023

Subjects

-

Tags

Tropical Medicine

Advisors

Farrag, Afaf E. , El-Sirafi, Magdi A. , El-Shahhar, Medhat H. , Hantar, Sherin M.

Authors

Mehrez, May Esmaeil

Accessioned

2017-04-26 12:37:44

Available

2017-04-26 12:37:44

type

M.D. Thesis

Abstract

Background: Today, hepatitis C virus (HCV) is the leading cause for liver transplantation (LT) and viral recurrence is almost universal. Objective: Whether hepatitis C virus recurrence occurs earlier and with greater severity for living donor liver transplantation (LDLT) than for deceased donor liver transplantation (DDLT). Methods: We evaluated preoperative and postoperative clinical, laboratory, and histological outcomes of 180 patients who underwent LT post-HCV infection (65 DDLT and 115 LDLT). Patients diagnosed for recurrence histologically were treated by combination therapy of pegylated IFN and RBV. Results: The LDLT group was significantly younger. CTP score was insignificant, while MELD score was higher in LDLT. The mean preoperative and postoperative HCV-RNA count was significantly lower in DDLT group (p= 0.012 and p= 0.027 respectively). At onset of recurrence, the onset and laboratory parameters were insignificant. Histologically, 59.57% and 41.89% patients in DDLT and LDLT group, respectively, diagnosed to have recurrence (p-value >0.05). Fibrosis and activity scores were significantly higher in the LDLT group (p= <0.01). The response to treatment was higher in DDLT group. Conclusions: HCV recurrence rates and severity of reinfection remain comparable for LD as well as DD organs; yet, LDLT does not significantly increase the risk and severity of HCV recurrence than DDLT.

Issued

1 Jan 2011

DOI

http://dx.doi.org/10.21473/iknito-space/33368

Details

Type

Thesis

Created At

31 Jan 2023