In this study, FPIR was done for 41 sibs how were +ve for one or two antibodies against B cell antigens, as well as 36 age and sex matched controls. 32 of those sibs underwent HLA studies for determination of DQB1 alleles. The mean FPIR in mU/L in sibs was 14.41 + 28.73 while in controls it was 79.41 + 44.32 and the differences statistically significant (P<0.001). The most frequent DQB1 alleles were 0201 (45.16%) 0202, 0304 (35.84% for each). 17 sibs (41.6%) had predisposing alleles and 7 sibs (17.7%) had protective alleles. It is recommended that sibs with +ve 2 autoantibodies, decreased FPIR and predisposing DQB1 alleles to be subjected to prevention trials against T1DM.