This essay is a study on the awake craniotomy procedure.Pharmacology of different drugs which are used in this procedure is discussed at first.Then, indications and advantages of awake craniotomy, patient selection, patient preparation and premedication are described in the preoperative management.Anesthetic management includes the patient positioning and basic monitoring, various anesthetic techniques and protocols used in the procedure, methods of airway and ventilation management, and types of regional block performed.Methods of intraoperative monitoring and cortical mapping are explained in details and finally management of the postoperative period is discussed.