Psoriasis is a multifactorial disease. Angiogenesis is a recognized event in psoriasis. Vascular endothelial growth factor (VEGF) is a key factor in promoting angiogenesis in the psoriatic plaques. In this study 15 patients with chronic stable psoriatic plaques were treated by pulsed-dye laser (PDL). Patients subjected to a mean of four laser sessions with two weeks apart. Laser parameters were: a wavelength of 600 nanometer, fluences of 7 and 8 Jouls/cm2, pulse durations of short (450 µsec) and long (1.5 msec), spot sizes of 3-10 millimeter with 10 - 15 % of overlapping. Results showed a clinical response varied from 20 - 100 % (mean 68.3%). Two cases (13.3%) showed complete (100%) clearance, 6 cases (40%) showed marked (80-95%), 2 cases (13.3) had moderate (60%) and the remaining 5 cases (33.3%) had mild (20-40%) improvement. A difference of high statistical significance was found between the level of VEGF gene in the treated plaques before laser therapy than after (p < 0.001), and between the VEGF protein quantity before laser therapy than after (p < 0.001). Conclusion: selective vascular destruction by PDL is an effective treatment modality for selected cases with few chronic stable psoriatic plaques not responsive to other forms of topical therapy.