This study was carried out in an aluminium factory in Helwan to assess neuropsychiatric disorders and its relation to occupational exposure to multiple stressors in aluminium industry through clinical assessment, neuropsychiatric tests, determination of serum aluminium, copper & urinary aluminium and environmental samples. It revealed increased prevalence of neurological symptoms among aluminium workers, most of the workers showed decreased scores in the performed neuropsychiatric tests as cognitive decline, memory affection, depression, anxiety and personality changes. All aluminium workers had elevated serum & urinary aluminium level compared to control group although environmental aluminium measurements are within permissible level.