The demographic characteristics of the women in the 2 studied groups were shown in Table (10).There were no statistically significant differences (p<0.05) between the 2 groups concerning the mean age, gestational age, parity and BMI. The mean adiponectin levels of the pregnant women in the study group were significantly lower than the controls (5.92 ±2.68 versus 15 ±3.61, respectively) (p<0.0001). This shows and confirms that midpregnancy hypoadiponectinemia is associated with GDM. Further studies is needed to elucidate the potential role of adiponectin in regulating insulin resistance and development of GDM.