Over a period of 24 months 45 patients with multiple warts were treated with 585 n.m pulsed dye laser every 1-2 weeks . laser parameters were : energy fluence 6-10 J/cm2 , spot size 5 mm , pulse duration 450 microseconds skin biopsies were taken for microscpical examination and DNA studies. We achieved clearance rate of 100% with mean number of sessions was 3. The eradication rate of HPV DNA by using PCR was 70% after one week from the second session. Thus, it could be concluded that , PDL is a safe and effective treatment for warts