The present study was done to assess the efficacy and advantage of fibrin therapy in anal fistulae. Ten patients with anal fistulae were treated by autologous fibrin glue, Preoperative mechanical bowel preparation as well as preoperative intravenous antibiotic were adapted. The group was matched for age, sex, fistula type and follow up duration 6 months. The non- invasive fibrin glue application was extremely satisfactory in 7 patients wheares 3 patients showed recurrence, mean hospital stay 1.5 day while patient discomfort was minimal. There was no postoperative impairment of anal sphincter function.