Pain is a common problem among cancer patients. There are multiple options for the management of cancer pain including a large variety of primary anticancer therapies, non invasive measures like systemic analgesics, and invasive procedures like regional analgesia, neurostimulatory techniques and neurodestructive surgical procedures. Despite of these facts uncontrolled cancer pain continues to be a common problem and many patients spend the last days of their lives suffering of pain. The procedures of regional analgesia are important part in the curriculum of cancer pain therapy and when properly applied the procedure can bring adequate pain relief. Safe and accurate conduction of the techniques of regional analgesia and percutaneous ethanol injection in bone metastases can be achieved under CT guidance.