Diabetic nephropathy is a serious complication in individuals with type II diabetes. Chemokines & their receptors have been implicated in the development of diabetic nephropathy. The aim of this work is to investigate the possible association of chemokine receptor CCR5 G59029 A gene polymorphism with diabetic nephropathy in patients with type II diabetes in order to find out the pathogenesis, risk of development & progression of nephropathy in type II diabetic patients. This study was conducted on 55 patients with type II DM including 15 patients with no nephropathy. (Control group) & 40 patients with nephropathy (Microalbuminuria group, Macroalbumiuria group & ESRD group). CCR5 59029 genotyping was performed using PCR followed by digestion with Bsp1286I restriction enzyme. Conclusion: There was no significant association of CCR5 G59029A gene polymorphism with diabetic nephropathy.