Astrocytic tumors are the most common primary tumors of the central nervous system. The present study was done on a total of 50 cases of astrocytic tumors. Tumors were classified according to the WHO classification into grades I, II, III, IV. The age incidence ranged from 6 years to 72 years. The majority of cases of glioblastomas were above 60 years. Male gender constituted 58% of the total cases. p53 expression showed a statistical significant value with mean age of cases and tumor grade. A statistical significance was also found between EGFR expression, mean age of cases and tumor grade. A highly significant statistical result was found on studying the correlation between p53 and EGFR in studied cases