Transdermal drug delivery plays an important role for many compounds, it deserves intensive study. Being a large surface, the skin is a good barrier for absorption. If drug applied locally it could be removed easily if toxicity appeared. Different technologies have been proposed for enhancing transdermal drug delivery of these are: Chemical enhancers, which increase permeability and control absorption, Recombinant interferon and elisa, Electroporation and inotophoresis and Sonophoresis.