Hs-CRP (an acute phase reactant) is considered a marker of atherosclerosis. Its level is affected by both genetic and environmental factors. We aim to study its relation to ischemic stroke and whether its gene G1059C polymorphism is related to CRP level. Significantly higher hs-CRP level is found in stroke patients than in controls. No association was found between CRP gene to G1059C polymorphism and serum level of hs-CRP or ischemic stroke.