Women with epilepsy face a host of challenges, including reproductive health disturbances. This study was designed to assess the frequency of reproductive health disturbances in epileptic females, examining the possible relationship between these disturbances and the different epilepsy types or the use of different AEDs. Subjects included 81 epileptic females aged 12 to 46 years, who were not receiving hormones; and 12 healthy age matched female volunteers. Menstrual history and trans-abdominal ovarian ultrasound were obtained. Endocrine variables were measured during the follicular phase as well as the luteal phase progesterone. A significant increase in seizure frequency was detected in patients with menstrual irregularities compared with those without . Moreover, patients on polytherapy had a statistically significant higher percentage of anovulation compared with those on monotherapy. Regarding the endocrine variables, there was a statistically significant higher values of follicular estrogen among patients (either treated or untreated) compared with the controls, and lower values of follicular progesterone among the treated patients compared with the untreated ones and the controls. In conclusion, polytherapy has a hazardous effect on the ovulatory function of WWE, although a significant differential effect of a specific antiepileptic drug or a specific epilepsy type on patients′ reproductive functions could not be proved.