Nocturnal enuresis is the involuntary and undesirable wetting that occurs at night or during sleep beyond the age of anticipated bladder control. The aim of this work was to evaluate the efficiency of enuresis alarm, in comparison to imipramine therapy for the treatment of nocturnal enuresis considering both the response and relapse rates. The present study included 40 patients suffering from PMNE. The mean age was 9.8 + 2.17 years. The study included both sexes with a male: female ratio 1:1.They were divided into 2 groups: First group included 11 girls and 9 boys who used imipramine (tofranil) in a dose of 25mg or 50mg according to their age and second group included 9 girls and 11 boys who used enuresis alarm. Each group was followed for 6 months, 3 months to detect response and another 3 months to detect relapse.Ninety percent of patients using enuresis alarm responded while 65% of patients using tofranil responded at the end of treatment. At 1and3 months after treatment was stopped the relapse rate was 11.1 and 16.7% respectively in alarm group while it was 23.07 and 46.1% respectively in tofranil group. Thirty five percent of patients in tofranil group did not respond completely while only 10% of patients in alarm group did not respond. So we can conclude that the enuresis alarm device was highly effective with low relapse rate whereas, imipramine was less effective with higher relapse rate in the treatment of PMNE.