Aims: Demand for feasible, safe, and durable weight reduction method is rising. Laparoscopic gastric plication is new bariatric restrictive procedure aimed at decreasing the stomach size without cutting any part of the stomach. Durability of the procedure is still under investigations by many surgeons around the world and the published data are still very scarce. This study aimed at measuring the stomach volume Changes after laparoscopic gastric plication using CT Volumetry technique and its effect on weight loss participate in the database and allowing better understanding of the procedure. Methods: Twenty morbidly obese patients who underwent gastric plication in the period between 2010 and 2012 were prospectively followed up after one and six months regarding excess weight loss and stomach size as measured using Ct Volumetry after ingesting effervescent material, to allow stomach distention, and analysed using SPSS 20. Results: This case series study included twenty morbidly obese patients (18 females) from Cairo University Hospital (CUH) in the period (8/2010 and 10/2012. Preoperative Body Mass Index (BMI 0) ranges between 35 and 62, (mean [±SD] BMI, 49.8±7). Excess Body weight (EBW) ranges between 28.4 and 91 Kg, (mean [±SD] EBW, 46.4±17.8 kg).Mean BMI was 44±6 (31-59) after one month (BMI 1), 38±6 (28-52) after six months (BMI 6). Mean Excess body weight loss (EBWL) was 26% ±8% (8%-36%) after one month (EBWL 1), and was 47%±14% (24%-73%) after six months (EBWL 6). Mean Pouch volume was 235 ±79 ml (110-446) after one month (Volume 1), 356±88 ml (243-568) after six months (Volume 6). Mean change in pouch volume was 121±68 ml (3-307). Mean percent change in pouch volume was 62±50 % (1%-192%). Weight loss after 6 months showed inverse relationship with the gastric volume at 6 months as measured by CT volumetry P=0.025. Stomach with higher volume will not restrict food intake as much as the less volume stomach. There was no statistically significant relationship between the % change in gastric volume and excess weight loss P=0.754. Conclusions: stomach volume has increase by a mean of 62% which highlights a question about longer term expansion. That increase didn’t correlate with weight loss which needs more patients to prove or disprove the relation.