Aim of Work: Analysis of chronic gastritis cases in 2 years duration, to detect rate of occurrence of different histological types, to reclassify cases according to the latest grading and staging systems and to compare the clinico-pathological features among Egyptian patients included in the study with registries of other countries.Methods: This was a retrospective study conducted at the Department of Pathology, Kasr Al Aini Hospital, Cairo University between January 2009 and December 2010. Analysis of 224 gastric biopsy specimens was done. We routinely make Hematoxylin/Eosin stained slides and perform Giemsa stain to check for H. pylori on all endoscopic gastric biopsies. Results: Out of two hundred & twenty four cases, H.pylori was found in 68.7% of the cases. Increased frequency of chronic gastritis was seen between 51 & 60 years. The most common clinical presentation was epigastric pain. The most common endoscopic finding was gastritis. The mean age of patients was 42 years and the age of patients ranged from 2.5 to 80 years. Females constituted 52% of cases while males were 48%. The mean age of female patients 41 years was less than that of male patients 43.4 years. Recommendations: For proper assessment of distribution of gastritis, multiple biopsies (at least five) from antrum, corpus & incisura angularis are important.