Hirschsprung’s disease is a developmental disorder of the enteric nervous system characterized by absence of ganglion cells in the myenteric and submucosal plexuses along a variable portion of the distal intestine. Hirschsprung’s disease or congenital aganglionic megacolon is relatively a common cause of intestinal obstruction in the newborn, occurring in approximately one of every 5000 live births. Diagnosis of Hirschsprung’s disease is based on the clinical picture (failure to pass meconium, constipation, abdominal distension, failure to thrive) and investigations (barium enemea, rectal mannometry, rectal biopsy).